Rho-Kinase Inhibition Improves Vasodilator Responsiveness During 1 Hyperinsulinemia in the Metabolic Syndrome
نویسندگان
چکیده
1 Hyperinsulinemia in the Metabolic Syndrome 2 Francesca Schinzari; Manfredi Tesauro; Valentina Rovella; Nicola Di Daniele; Paolo 3 Gentileschi; Nadia Mores; Umberto Campia; Carmine Cardillo 4 5 Affiliation 6 From the Departments of Internal Medicine and Pharmacology, Catholic University 7 Medical School, Rome, Italy; Departments of Internal Medicine and Surgery, 8 University of Tor Vergata, Rome, Italy; and Division of Cardiology, Northwestern 9 University Feinberg School of Medicine, Chicago, IL, USA. 10 11 Running Head 12 Rho-kinase & vascular reactivity in the metabolic syndrome. 13 14 Contact Information: 15 Carmine Cardillo, MD 16 Istituto di Patologia Speciale Medica e Semeiotica Medica 17 Università Cattolica del Sacro Cuore 18 Largo Gemelli 8, 00168 Rome, Italy 19 Tel +39 (06) 3015-4846 20 Fax +39 (06) 3015-7232 21 E-mail [email protected] 22 23 Articles in PresS. Am J Physiol Endocrinol Metab (July 24, 2012). doi:10.1152/ajpendo.00206.2012
منابع مشابه
Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome.
In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhibition with fasudil restores insulin-stimulated vasodilator reactivity and that oxidative stress ...
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